CENTER FOR DEVELOPMENT OF ANTI-SPERM CONTRACEPTIVES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。目的：本中心的重点是作为避孕靶点的配子。近年来，在基因组学和蛋白质组学、细胞生物学、受精研究和药物发现方面取得了显著进展。这些进展结合起来，为针对配子的避孕干预开辟了新的可能性，这可能是以前想象过的，但无法实现。我们的大多数项目都是针对精子的，尽管有一个项目提出了一个潜在的卵子目标。抗精子避孕会阻碍精子功能或精子发育。我们中心的项目包括这两个目标。该中心的一个主要主题是小分子抑制剂，以阻止精子功能。我们的中心正在积极研究精子质膜蛋白，在精卵相互作用中发挥作用，我们建议筛选抑制这些精子蛋白的小分子，从而防止受精。第二个主题是阻止精子发育。新的药理学策略脱轨精子生产的复杂过程中提出的。我们所有研究精子发育的人都知道精子发生的重要进展，并意识到新的可行的避孕目标正在被确定。因此，我们建议扩大我们在精子发生方面的目标清单，增加我们开发节育新产品的范围和机会。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The focus of this Center is the gamete as a contraceptive target. Remarkable advances have occurred recently in genomics and proteomics, cell biology, fertilization research and drug discovery. These advances have combined to open new possibilities for contraceptive intervention, directed against gametes, that may have been previously imagined but were unattainable. Most of our projects target sperm, though one project proposes a potential egg target. Anti-sperm contraception can block sperm function or sperm development. Our Center's projects include both targets. A major theme of the Center is small molecule inhibitors to block sperm function. Our Center is actively studying sperm plasma membrane proteins that function in sperm-egg interaction and we propose screens for small molecules that inhibit these sperm proteins and thus prevent fertilization. A second theme is to block sperm development. Novel pharmacological strategies to derail the complex process of sperm production are proposed here. All of us who study sperm development are aware of important advances in spermatogenesis and realize that new, feasible contraceptive targets are being identified. Thus, we have proposed an expansion of our target list in spermatogenesis, increasing our scope and chances of developing new products for birth control.