Methodology Core

核心单位人员将参与提供以下四项主要服务： 设计、统计支持、FRACTIONAL/北京/MOST和OAI流行病学分析和管理。 尽管为了便于演示，可以单独考虑这些服务，但它们实际上代表了 这是一个集成功能网络，将以多种方式促进MCRC的绩效。一是 这些服务的集中有助于整合中心的多个研究项目， 以方便他们的管理。二是核心服务功能将提供补充支撑 通过这项MCRC提案资助的流行病学和其他临床研究项目，以及 正在或将由其他来源供资的其他项目的数目。该核心单元已经提供 为多个外部资助的项目提供实质性的研究支持（例如，目前的四个R-Ol/U-01），并将 在下一个五年周期中继续这样做。RESCU还将提供关键的启动支持， 在赠款周期内发展的项目。第三，核心将为其他研究活动提供服务 在关节炎中心，包括基础和临床研究项目，如血管炎和 硬皮病第四，核心资金将使我们的工作人员能够继续为研究人员提供咨询支持， 其他关节炎单位 核心单位安排将建立一个资源网络，扩大工作人员的职能 工作人员的工作不仅限于其具体的项目任务，而且有助于有效利用工作人员的时间。的两个关键特征 这个中心资源是这个支持单位成员的共享办公空间， 频繁的互动，以及每周的工作人员会议，其中正在进行的和拟议的研究项目， 批判性地评价。因此，这一成功的核心单位的继续将提供一套集中的、 共享资源，这将提高我们在中心特别强调的领域的生产力， 为需要设计和分析建议的其他关节炎研究者提供资源支持。这 核心单位的外部支持功能将有助于实现NIH中心的主要目标之一 程序.

Core unit personnel will be involved in providing each of the following four major services: project design, statistical support, Framingham/Beijing/MOST and OAI epidemiologic analyses and administration. Although these services can be considered separately for ease of presentation, they in fact represent a rich network of integrated functions that will contribute to MCRC performance in a number of ways. First, the centralization of these services helps to integrate the multiple research projects of the Center and will also serve to facilitate their administration. Second, the core service functions will provide supplemental support for projects in epidemiology and other clinical research funded through this MCRC proposal and for a number of other projects that are or will be funded from other sources. This core unit already provides substantial research support for multiple externally funded projects (e.g. four current R-Ol/U-01's) and will continue to do so during the next 5 year cycle. RESCU will also provide critical start up support for new projects that evolve during the grant cycle. Third, the core will provide services to other research activities in the Arthritis Center including basic and clinical research projects such as those in vasculitis and scleroderma. Fourth, core funds will enable our staff to continue their consultative support of researchers at other arthritis units. The core unit arrangement will create a network of resources that extends the functions of staff beyond their specific project assignments and facilitates the efficient use of staff time. Two key features of this central resource are the shared office space of members of this support unit which leads them to frequent interactions, and the weekly staff meetings in which ongoing and proposed research projects are critically evaluated. The continuation of this successful core unit will thus provide a set of centralized and shared resources that will enhance our productivity in an area of special Center emphasis and that will contribute to a resource in support of other arthritis investigators who need design and analysis advice. This external support function of the core unit will help to achieve one of the major goals of the NIH Centers Program.