COMPARISON HYPOXIA, GLUCOSE UPTAKE RAT R3230 TUMORS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。目标1使用校准的缺氧标志物EF5验证体内缺氧标志物铜()-ATSM在肿瘤中的作用。这两种标记物在肿瘤中的分布和数量将通过microPET和免疫组织化学方法进行比较。目的#2比较磁共振血氧水平依赖成像(BOLD)和铜()-ATSM-PET的信号。目标#3比较体内摄取(18)FDG与肿瘤冰冻切片成像生物发光测量的葡萄糖在肿瘤中的分布。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Goal #1 Validate the in-vivo hypoxia marker Cu(64)-ATSM in tumors using the calibrated hypoxia marker EF5. The two markers are to be compared concerning their distribution and their amount in the tumor, using microPET and immunohistochemistry. Goal #2 Compare the signal of blood-oxygen-level-dependent imaging (BOLD), as determined with MRI, with the signal of Cu(64)-ATSM-PET. Goal #3 Compare the in-vivo uptake of (18)FDG with the distribution of glucose in the tumor, as measured by imaging bioluminescence in cryosections of tumors.