T-TUBLES IN MLPKO

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这是我们的心血管研究团队和Maryann Martone博士及其同事的持续研究成果。研究目的是阐明心脏t管结构与心力衰竭相关的异常。研究包括扩张型心肌病突变小鼠模型心肌的EM和LM水平分析。Maryann博士等人开发的记录t管三维结构的独特技术有望揭示心脏兴奋-收缩耦合的关键组成部分中未知的疾病相关异常。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a continuous research effort by our cardiovascular research team and Dr. Maryann Martone and her fellows. Studies aim to elucidate the heart failure-related abnormalities in cardiac t-tubles structure. Studies include EM and LM level analysis of myocardium obtained from mutant mouse model of dilated cardiomyopathy. The unique technology developed by Dr. Maryann et al. to document 3D structure of t-tubes are expected to unveil unknown disease-related abnormalities in this critical component of cardiac excitation-contraction coupling.