T-TUBLES IN MLPKO

MLPKO 中的 T 型管

• 批准号: 7957604
• 负责人: MASAHIKO HOSHIJIMA
• 金额: $ 6.23万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-15 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7957604
• 关键词: Cardiac; Cardiovascular system; Computer Retrieval of Information on Scientific Projects Database; Coupling; Dilated Cardiomyopathy; Disease; Funding; Grant; Heart failure; Image Analysis; Institution; Myocardium; Research; Research Personnel; Resources; Source; Structure; Technology; Tube; United States National Institutes of Health; mutant mouse model; three dimensional structure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a continuous research effort by our cardiovascular research team and Dr. Maryann Martone and her fellows. Studies aim to elucidate the heart failure-related abnormalities in cardiac t-tubles structure. Studies include EM and LM level analysis of myocardium obtained from mutant mouse model of dilated cardiomyopathy. The unique technology developed by Dr. Maryann et al. to document 3D structure of t-tubes are expected to unveil unknown disease-related abnormalities in this critical component of cardiac excitation-contraction coupling.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这是我们的心血管研究团队和Maryann Martone博士及其研究员的持续研究努力。 研究旨在阐明心力衰竭相关的心脏t管结构异常。 研究包括从扩张型心肌病突变小鼠模型获得的心肌的EM和LM水平分析。 Maryann博士等人开发的独特技术记录了t管的3D结构，预计将揭示心脏兴奋-收缩耦合的这一关键组成部分中未知的疾病相关异常。