CANCER CHEMOPREVENTIVE AND ANTIOXIDANT AGENTS FROM ALLIUM SPECIES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。本研究的目的是分离、鉴定和鉴定葱属植物中具有与人类癌症化学预防相关的生物活性的内源成分，如洋葱、大蒜和大葱。第二阶段酶诱导活性的测定，以及一组选定的抗氧化功能或生理相关性的选择，将分别作为初级和二级分析，指导从选定的洋葱蔬菜提取物中分离和纯化生物活性成分。在经常食用的水果和蔬菜中确定促进健康的植物化学物质，如果它们最终被证明对人类有效，将有助于农业的有效性和可持续性，并鼓励公众做出促进健康的食品选择。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this study is to isolate, identify and characterize endogenous components in Allium species, such as onion, garlic and green onion that possess biological activities relevant to cancer chemoprevention in humans. Determination of phase II enzyme inducing activity, and a set of selected antioxidant functions or physiological relevance will be used, respectively, as primary and secondary assays to direct the isolation and purification of bioactive principles from extracts of selected Allium vegetables. The identification of health-promoting phytochemicals in commonly consumed fruits vegetables, if they are ultimately shown to be efficacious in humans, will contribute to the effectiveness and sustainability of agriculture as well as encourage the public to make health-promoting food choices.