CHARACTERIZE DE NOVO SYNTHESIZED BETULINOL DERIVATIVES: DVLP ANTI HIV DRUGS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。合成桦木醇衍生物的免疫缀合物，以开发潜在的抗癌和抗STD/抗HIV药物。质谱法用于鉴定这些化合物中的几种。这是通过nanospray MS和MS/MS实现的，使用聚丙烯衍生物作为内部校准标准。计划完全解决断裂机制，以便更安全地区分某些异构体，并进一步研究新化合物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Immunoconjugates of betulinol derivatives are synthesized in order to develop potential anti-cancer and anti-STD / anti-HIV drugs. Mass spectrometry was used for the identification of several of these compounds. This was achieved by nanospray MS and MS/MS, using a polypropyl derivative as the internal calibration standard. It is planned to completely solve the fragmentation mechanism in order to more safely distinguish certain isomers, and to examine further new compounds.