The Turnover Rate of Human CD4+CD25+ T cells in vivo

我们的身体在受到感染生物的攻击时会产生免疫反应。这一反应的中心参与者是我们的白细胞，即对抗感染性病原体的士兵。然而，这些白细胞受到严格的命令，不能用友军的炮火攻击无助的组织，这些命令部分来自一种被称为调节细胞的特殊类型的白细胞。关于这些调节细胞是如何在体内培养的，以及它们是从哪里招募来的，人们知之甚少。该项目的主要目标是确定这些细胞是否从响应性免疫大军的队伍中招募，如果是，这涉及哪些额外的培训？我们还将确定，80岁以上的老年人的老化和潜在功能失调的免疫大军是否可以像年轻人一样被培养成调节细胞。这项研究的时机非常合适，因为我们将使用我们已经开发的两种不同的新型人类实验系统，这两种系统使我们能够在体内研究人类的免疫细胞和免疫反应。

Our bodies mount immune responses when attacked by infectious organisms. The central participants in this response are our white cells, the soldiers that combat the infective agents. However, these white cells are under strict orders not to attack helathy tissue by friendly fire and these commands come in part from a particular kind of white cell known as regulatory cells. Little is known about how these regulatory cells are trained in the body and where they are recruited from. The main objective of this project is to determine if these cells are recruited from the ranks of the responsive immune army and if so, what additional training does this involve ? We will also determine if the ageing and potentially dysfunctional immune army in elderly humans who are over 80 years old can be trained to become regulatory cells in the same way as those in young people. The timing of this study is highly opotimal as we will be using two different novel human experimental systems that we have already developed, that enable us to investigate immune cells and immune responses in humans in vivo.