EVALUATION OF GUIDE TREE IMPRINTING AND PHYLOGENETIC TREE VARIATION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们正在评估的程度，指导树印迹偏见在渐进的多个比对方法在一些对齐和同源性重建方法。使用指导树独立的多序列比对方法，最佳的相对于其implementation评分模型，和树拓扑结构差异的措施，我们正在评估的比对和同源性重建方法的组合中的印迹偏差的程度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are assessing the extent of guide tree imprinting bias in progressive multiple alignment methods across a number of alignment and phylogeny reconstruction methods. Using a guide tree independent multiple sequence alignment method, optimal with respect to its alignmment scoring model, and measures of tree topology difference we are evaluating the extent of imprinting bias in combinations of alignment and phylogeny reconstruction methods.