STRUCTURE OF FLAVIVIRUS ENVELOPE PROTEIN

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。像登革热和西尼罗河这样的黄病毒感染正在美国出现，被认为是生物恐怖威胁，因为病毒可以以传染性的形式被雾化。我们的包膜蛋白晶体是这种黄病毒的第一种。人们希望，高分辨结构将有助于更好地理解融合机制，并将有助于抑制剂的开发。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Flavivirus infections such as Dengue and West Nile are emerging in the United States and are considered bioterrorist threats as the virus can be aerosolized in an infectious form. Our envelope protein crystals are the first for this species of flavivirus. It is hoped that a high resolution structure will lead to a better understanding of the fusion mechanism and will aid in the development of inhibitors.