EVALUATION OF THE ROLE OF POWER DOPPLER SONOGRAPHY IN THE DIAGNOSIS OF HEMOPH

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。血友病性关节病是严重血友病最常见的并发症。目前，MRI用于诊断血友病性滑膜炎（早期关节疾病）。然而，它是昂贵的，并没有提供信息的活动性关节滑膜炎活动与非活动性疾病。能量多普勒超声可以检测到血管的变化，这对定量疾病活动是有用的。与MRI相比，它也很便宜，并且可以在儿童中进行而无需镇静。因此，其在血友病性滑膜炎诊断中的作用将被评估。此外，将研究其作为诊断早期关节疾病以预防慢性关节病的筛查工具的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hemophilic joint disease is the most common complication of severe hemophilia. Currently, MRI is used to diagnose hemoilic synovitis (early joint disease). However, it is expensive and does not give information on activity of joint synovitis-active vs inactive disease. Power doppler sonography can detect changes in vacsularity, which is useful for quantitating disease activity. It is also inexpensive compared to MRI and can be performed in children without sedation. Hence, its role in diagnosing hemophilic synovitis will be evaluated. Also, its role as a screening tool for diagnosing early joint disease to prevent chronic arthropathy will be studied.