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SAFETY AND EFFICACY OF HYDROXYUREA AS A PROPHYLACTIC THERAPY FOR SICKLE CELL

SAFETY AND EFFICACY OF HYDROXYUREA AS A PROPHYLACTIC THERAPY FOR SICKLE CELL
羟基脲作为镰状细胞预防疗法的安全性和有效性
批准号：
7377385
负责人：
Eugene P Orringer
金额：
$0.17万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
项目状态：
已结题
起止时间：
2005-12-01 至 2006-11-30
来源：
https://reporter.nih.gov/project-details/7377385
关键词：
SAFETYEFFICACYHYDROXYUREAPROPHYLACTICTHERAPY

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中文摘要
翻译
本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这项双盲随机研究的目的是：a)比较接受羟脲治疗的患者与接受安慰剂治疗的对照组的临床病程；B)定量观察羟基脲对镰状细胞性贫血患者红细胞中胎儿血红蛋白生成的影响。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this double-blind, randomized study is: a) to compare the clinical course of patients receiving hydroxyurea to a control group receiving placebo and; b) to quantitate the effect of hydroxyurea on fetal hemoglobin production in the red blood cells of patients with sickle cell anemia.
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PERMEABILITY & METABOLISM OF RBC FROM PATIENTS WITH HEMOLYTIC ANEMIAS
CLINICAL TRIAL: NEUROPSYCHOLOGICAL DYSFUNCTION AND NEUROIMAGING ABNORMALITIES IN
NEUROPSYCHOLOGICAL DYSFUNCTION AND NEUROIMAGING ABNORMALITIES IN SCD
PERMEABILITY & METABOLISM OF RBC FROM PATIENTS WITH HEMOLYTIC ANEMIAS
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