HUMAN MODELS OF SICKLE CELL VASCULAR DAMAGE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。我们将在正常对照和镰状细胞性贫血患者中研究短时间缺氧后真皮毛细血管血流和输送到深部组织的血氧的变化。这些反应将被标准化，以便以后用于研究可能改善血液流动和氧气输送的药理学干预措施。血氧水平输送将通过磁共振成像测量，皮肤毛细血管血流将使用激光多普勒血流测量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Changes in dermal capillary blood flow and blood oxygen delivered to deep tissue in response to a brief period of hypoxia will be studied in normal controls and subjects with sickle cell anemia. These responses will be standardized so they can later be used to study pharmacological interventions that may improve blood flow and oxygen delivery. Blood oxygen level delivery will be measured by magnetic resonance imaging and dermal capillary blood flow will be measured using laser-Doppler flow.