OUTCOME MODIFYING GENES IN SICKLE CELL DISEASE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目的是收集三个机构的1000名镰状细胞病患者的临床信息和血液样本，然后看看是否有某些遗传因素(即所谓的“基因”)可能会改变疾病的严重程度。这项研究试图找到那些使镰状细胞疾病的表达不那么严重的基因，以及那些使其变得更严重的基因。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to collect both clinical information and blood samples from 1000 patients at three institutions with sickle cell disease, and then to see if there are certain inherited factors (called "genes") that may modify the severity of the disease. This study seeks to find those genes that make the expression of sickle cell disease less severe and those genes that make it more severe.