CEREBROSPINAL FLUID HIV-1 AND COGNITIVE FUNCTION IN PATIENTS RECEIVING THERAPY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。这项观察性研究的目的是观察血液中的HIV水平与脑脊液（CSF）中的HIV水平的比较，CSF是在强效抗逆转录病毒治疗前后在大脑和脊髓周围发现的液体。还将测量血液和CSF中不同抗逆转录病毒药物的水平，并评估这些药物的效果。要参加本研究，受试者还必须参加抗逆转录病毒治疗研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this observational study is to see how levels of HIV in the blood compare to those in cerebrospinal fluid (CSF), a fluid found around your brain and spinal cord before and after the administration of potent antiretroviral therapy. Also the levels of the different antiretroviral drugs will be measured in the blood and in the CSF and the effects of those drugs will be evaluated. To be in this study, persons also must be participating in an antiretroviral therapy study.