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QUANTIFYING HIV 1 RNA IN CEREBROSPINAL FLUID & BLOOD

QUANTIFYING HIV 1 RNA IN CEREBROSPINAL FLUID & BLOOD
定量脑脊液中的 HIV 1 RNA
批准号：
6308605
负责人：
ANN PETRU
金额：
$1.75万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2000-11-30
来源：
https://reporter.nih.gov/project-details/6308605
关键词：
AIDS /HIV neuropathy blood chemistry cerebrospinal fluid child (0-11) clinical research genetic strain human immunodeficiency virus 1 human tissue latent virus infection pediatric AIDS virus RNA virus load

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英文摘要
The hypothesis of this protocol is that increases in HIV-1 viral load in the central nervous system (CNS) of infants and children infected with the virus will be associated with a poor neurological outcome. Also, we will examine that as more children receive combination therapy with antiretrovirals that have varying degrees of CNS penetration, the CNS will act as a reservoir for virus and viral RNA from the CNS will have different resistance patterns than isolates from the peripheral blood. We also propose that virus isolated from the CSF of children with HIV encephalopathy is genetically different from virus in the CSF of neurologically asymptomatic children.
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