Structure-based Analysis of Apocarotenoid Biosynthesis

类维甲酸是动物体内必不可少的信号分子，已成为常见的化学防护剂。 减肥药。类维甲酸的生物合成途径始于类胡萝卜素的裂解 类胡萝卜素裂解双加氧酶(CCD)家族最先在植物中发现。在植物中，ccd 参与植物激素脱落酸和一种控制植物的新激素的生物合成 建筑。在动物体内，CCDs负责维甲酸的生物合成，特别是维生素A，它 是视力所必需的，以及对正常发育至关重要的维甲酸。目前，没有高 存在任何电荷耦合器件的分辨率结构信息。具有一个或多个ccd的结构，在结构上 可以对植物中的酶和代谢途径工程进行指导性方法，以允许 控制植物结构以及提高营养质量。在动物身上，这种方法可能会导致 对视觉生色团和信号分子维甲酸的产生有更深入的了解 酸。模式生物拟南芥中的ccd家族提供了一系列与 系统地剖析了复杂机械结构的电荷耦合器件的结构和功能特征。

Retinoids are essential signaling molecules in animals and have become common chemo-preventitive dietary agents. The retinoid biosynthetic pathway begins with the cleavage of a carotenoid by a member of the Carotenoid Cleavage Dioxygenase (CCD) family of enzymes first discoverd in plants. In plants, CCDs participate in the biosynthesis of the phytohormone abscisic acid and a novel hormone that controls plant architecture. In animals the CCDs are responsible for the biosynthesis of retinoids, notably vitamin A, which is necessary for vision, and retinoic acid, which is critical to normal development. Currently, no high resolution structural information for any CCD exists. With the structure of one or more CCDs, a structurally guided approach towards enzyme and metabolic pathway engineering in plants could be done to allow for the control of plant architecture as well as increase nutritional quality. In animals, this approach could lead to a greater understanding of the production of the visual chromophore and to the signaling molecule, retinoic acid. The CCD family in the model organism Arabidopsis thaliana provides a collection of related genes for the systematic dissection of the structural and functional features of the mechanistically complex CCDs.