HDAC 1 and 5 in Periodontitis

牙周炎的严重并发症是骨丢失和牙齿松动。尽管这种疾病的流行，目前的治疗方法不能直接阻止骨质流失。我们最近的实验室研究表明，抑制组蛋白去乙酰化酶（HDAC）的活性与非常低剂量的抑制剂可以有效地抑制这种牙周炎的骨丢失。本项目旨在研究HDAC 1和HDAC 5的特异性靶向抑制剂，通过促进骨形成和减少骨丢失来治疗牙周炎。

Bone loss and tooth loosening are serious complications in periodontitis. Despite the prevalence of this disease current treatments do not directly stop the bone loss. Our recent laboratory studies show inhibiting histone deacetylase (HDAC) activity with very low doses of inhibitors can effectively suppress this bone loss in periodontitis. This project aims to investigate specific targeting inhibitors of HDAC 1 and HDAC 5 to treat periodontitis by enhancing bone formation and reducing bone loss.