ROLE OF INSULIN RESISTANCE AND CV RISK IN CORONARY ARTERY DISEASE IN DIABETES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这是一项研究心脏危险因素的患者遗传易感糖尿病或现有的2型糖尿病。将从已完成心脏导管插入术的患者人群中招募患者，并根据家族史、基于BMI的肥胖存在和口服葡萄糖耐量试验（OGTT）结果将其分为6组。 本方案将通过病史、体格检查和实验室测量，包括使用胰岛素钳夹技术评估胰岛素敏感性，对非糖尿病和2型糖尿病受试者进行详细的CV风险特征。心血管疾病的程度将通过颈动脉和降主动脉的MRI进一步研究。还将通过血管造影结果评估冠状动脉。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a study of cardiac risk factors in patients genetically pre-disposed to diabetes or with existing type 2 diabetes. Patients will be recruited from a population of patients who have already completed a cardiac catherization, and they will be placed into 6 groups based upon family history, presence of obesity based upon BMI, and results of an oral glucose tolerance test (OGTT). This protocol will perform a detailed CV risk profile on non-diabetic and type 2 diabetic subjects by history, physical examination, and laboratory measurement, including assessment of insulin sensitivity using the insulin clamp technique. The extent of cardiovascular disease will be further studied by MRI of the carotid arteries and descending aorta. The coronary arteries will also be assessed by angiographic findings.