ROLE OF INSULIN RESISTANCE AND CV RISK IN CORONARY ARTERY DISEASE IN DIABETES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一项关于遗传倾向于糖尿病或现有2型糖尿病患者的心脏危险因素的研究。患者将从已经完成心脏插管的患者中招募，他们将根据家族史、基于体重指数的肥胖情况以及口服葡萄糖耐量测试(OGTT)的结果被分成6组。 该方案将通过病史、体检和实验室测量对非糖尿病和2型糖尿病受试者进行详细的心血管风险分析，包括使用胰岛素钳技术评估胰岛素敏感性。心血管疾病的程度将通过颈动脉和降主动脉的MRI进一步研究。冠状动脉也将根据血管造影结果进行评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a study of cardiac risk factors in patients genetically disposed to diabetes or with existing type 2 diabetes. Patients will be recruited from a population of patients who have already completed a cardiac catherization, and they will be placed into 6 groups based upon family history, presence of obesity based upon BMI, and results of an oral glucose tolerance test (OGTT). This protocol will perform a detailed CV risk profile on non-diabetic and type 2 diabetic subjects by history, physical examination, and laboratory measurement, including assessment of insulin sensitivity using the insulin clamp technique. The extent of cardiovascular disease will be further studied by MRI of the carotid arteries and descending aorta. The coronary arteries will also be assessed by angiographic findings.