ROLE OF INSULIN RESISTANCE AND CV RISK IN CORONARY ARTERY DISEASE IN DIABETES

胰岛素抵抗和心血管风险在糖尿病冠状动脉疾病中的作用

• 批准号: 7627478
• 负责人: KENNETH CUSI
• 金额: $ 0.33万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7627478
• 关键词: Cardiac; Cardiovascular Diseases; Carotid Arteries; Computer Retrieval of Information on Scientific Projects Database; Coronary Arteriosclerosis; Coronary artery; Descending aorta; Diabetes Mellitus; Family history of; Funding; Grant; Institution; Insulin; Insulin Resistance; Laboratories; Magnetic Resonance Imaging; Measurement; Non-Insulin-Dependent Diabetes Mellitus; OGTT; Obesity; Patients; Physical Examination; Population; Protocols documentation; Recording of previous events; Recruitment Activity; Research; Research Personnel; Resources; Risk; Risk Factors; Role; Source; Techniques; United States National Institutes of Health; base; diabetic; insulin sensitivity; non-diabetic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a study of cardiac risk factors in patients genetically disposed to diabetes or with existing type 2 diabetes. Patients will be recruited from a population of patients who have already completed a cardiac catherization, and they will be placed into 6 groups based upon family history, presence of obesity based upon BMI, and results of an oral glucose tolerance test (OGTT). This protocol will perform a detailed CV risk profile on non-diabetic and type 2 diabetic subjects by history, physical examination, and laboratory measurement, including assessment of insulin sensitivity using the insulin clamp technique. The extent of cardiovascular disease will be further studied by MRI of the carotid arteries and descending aorta. The coronary arteries will also be assessed by angiographic findings.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这是一项针对遗传性糖尿病患者或现有 2 型糖尿病患者的心脏危险因素的研究。 将从已经完成心导管插入术的患者群体中招募患者，并根据家族史、基于 BMI 的肥胖情况以及口服葡萄糖耐量试验 (OGTT) 的结果将他们分为 6 组。 该方案将通过病史、体检和实验室测量，包括使用胰岛素钳技术评估胰岛素敏感性，对非糖尿病和 2 型糖尿病受试者进行详细的 CV 风险概况。 心血管疾病的程度将通过颈动脉和降主动脉的 MRI 进一步研究。 冠状动脉也将通过血管造影结果进行评估。