A PHARMACOLOGICAL ANALYSIS OF THC IN HUMANS (01)

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。建立口服液THC作为辨别性刺激，并表征其对行为和认知的影响。假设THC将作为一种歧视性刺激发挥作用，并产生通常在服用大麻后出现的其他效果。为了确定口服THC对人类的影响是否也可以归因于阿片类药物、GABA和DA系统的间接参与。假设阿片激动剂氢吗啡酮和GABA调节剂三唑仑将部分替代THC，并在大多数实验指标上具有与THC相似的作用。相反，假设间接DA激动剂哌醋甲酯不会与THC分享辨别刺激效应，并将对大多数实验措施产生相反的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To establish oral THC as a discriminative stimulus and characterize its effects on behavior and cognition. It is hypothesized that THC will function as a discriminative stimulus and produce other effects typically seen following cannabis administration. To determine if the effects of oral THC in humans can also be attributed to indirect involvement of the opioid, GABA and DA systems. It is hypothesized that the opioid agonist hydromorphone and GABA modulator triazolam will partially substitue for THC and will have similar effects to THC on most expermental measures. In contrast it is hypothesized that the indirect DA agonist methylphenidate will not share discriminative-stimulus effects with THC and will have opposite effects on most experimental measures.