INSULIN RESISTANCE AND VASCULAR DYSFUNCTION IN ASIAN INDIANS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是调查为什么与生活在美国的白种人相比，亚洲印度人患糖尿病和冠心病的风险更高。本研究将检验亚洲印度人与年龄和体重指数匹配的白种人相比具有胰岛素抵抗、体脂分布改变和内皮功能障碍的假设。我们还将确定胰岛素增敏剂是否可以改善亚洲印度人的胰岛素抵抗和逆转内皮功能障碍，与年龄和BMI匹配的高加索人相比。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to investigate why Asian Indians are at a higher risk for developing diabetes and coronary heart disease compared to Caucasians living in the U.S. This study will test the hypothesis that Asian Indians are insulin resistant, exhibit altered body fat distribution and have endothelial dysfunction compared to Caucasians matched for age and BMI. We will also determine whether insulin sensitizers can improve insulin resistance and reverse the endothelial dysfunction in Asian Indians compared to Caucasians matched for age and BMI.