INFANT HEART SURGERY: CNS SEQUELAE OF HEMATOCRIT MANAGEMENT

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。到目前为止，临床研究还没有确定在婴儿修复性心脏直视手术中用于支持重要器官的低温低流量体外循环和全循环停搏前降温期间血液稀释的最佳程度。本先导性研究的目的是为未来的前瞻性随机临床试验提供数据，比较两种红细胞压积管理策略在体外循环停搏或低流量前的体外循环降温阶段对接受修复性心脏手术的婴儿和儿童的神经系统和发育结果。我们的目标将在一项前瞻性、随机、单中心试验中实现。治疗策略将根据神经学参数进行比较。居住在当地的患者将在12个月时评估神经学和发育结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Clinical studies to date have not determined the optimal degree of hemodilution during cooling prior to hypothermic low-flow cardiopulmonary bypass and total circulatory arrest used to support vital organs during reparative open heart surgery in infants. The purpose of the present pilot study is to provide data for a future prospective randomized clinical trial comparing neurologic and developmental outcome of two strategies of hematocrit management during the cooling phase of cardiopulmonary bypass, prior to circulatory arrest or low-flow, in infants and children undergoing reparative open heart surgery. Our goals will be pursued in a prospective, randomized, single-center trial. The treatment strategies will be compared with respect to neurologic parameters. Neurologic and developmental outcomes will be assessed at 12 months in those patients who live locally.