RANDOMIZED, MULTICENTER TACROLIMUS WITH STEROID VS STEROID FREE (SNS-01)

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。该研究的目的是比较传统类固醇方案（Prograf、MMF、类固醇和标准达利珠单抗诱导，直到移植后第二个月）与无类固醇方案（Prograf、MMF和达利珠单抗诱导，直到移植后第六个月）的安全性和有效性。本协议的统计部分描述了精确的端点定义和功率考虑。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study objective is to compare the safety and efficacy of a traditional steroid based-protocol (Prograf, MMF, steroids and standard daclizumab induction until the second month post-transplant) to a steroid-free protocol (Prograf, MMF and daclizumab induction until the sixth month post-transplant). Precise endpoint definition and power considerations are described in the statistical section of this protocol.