INVESTIGATION OF FACIAL ASYMMETRY IN PATIENTS WITH CRANIOFACIAL ANOMALIES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。本研究的总体目的是描述颅面畸形患者的颅面特征。唇腭裂患者将与正常人群进行比较。面部的生长受到手术的影响--外科医生在解决这些儿童的三维缺陷时必须考虑到“第四维”（时间）。因此，记录唇腭裂修复后几个面部标志的人体测量值随年龄的变化非常重要。 用卡尺和直尺进行客观测量可以有效地记录这些测量结果，但可能很耗时，需要专家才能获得。新兴的三维数字摄影测量技术可以帮助克服这些困难。我们建议，三维数字摄影测量技术将系统和定量地获得形态测量的时间效率的方式，更好地定义颅面异常患者的面部畸形。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The general aim of this study is characterization of craniofacial features in patients with craniofacial anomalies. Patients with cleft lip and palate will be compared with normal population. Growth of face is affected by surgery--a surgeon has to take into account the 'fourth dimension' (of time) while addressing three-dimensional defects in these children. Therefore, it is important to record changes in anthropometric measurements of several facial landmarks with age after repair of cleft lip and palate. Objective measurements with calipers and rulers are powerful to record such measurements, but can be time-consuming and require experts to obtain them. Newly emerging techniques in 3D digital photogrammetric techniques can help overcome these difficulties. We propose that 3D digital photogrammetric techniques will systematically and quantitatively obtain morphometric measurements in a time-efficient manner and better define facial dysmorphology in patients with craniofacial anomalies.