EFFECT OF AORTIC IMPEDANCE ON MYOCARDIAL RELAXATION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。左心室收缩功能正常或接近正常的充血性心力衰竭被称为舒张性心力衰竭。根据申请人的说法，1995年至少有50%的65岁以上因心力衰竭住院的患者（超过35万人）患有原发性舒张性心力衰竭。舒张期心力衰竭的再住院率和费用与收缩期心力衰竭相当，尽管死亡率较低。尽管它很普遍，但舒张衰竭的生理机制尚不清楚，最佳诊断策略尚未确定，也没有任何治疗方法可以降低该疾病的死亡率。在这项研究中，65岁以上的高血压患者和年龄匹配的对照组将使用非侵入性测量动脉僵硬度和心肌松弛度。将测试各种血管扩张剂对这些结果的影响，以确定对动脉僵硬的不同药理作用是否会导致对心肌舒张的不同影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. (from CRISP website) Congestive heart failure in the presence of normal or near normal left ventricular systolic function is referred to as diastolic heart failure. According to the applicant, it is thought that at least 50% of patients older than 65 years hospitalized with heart failure in 1995 (over 350,000 patients), had primary diastolic heart failure. Rates of re-hospitalization and costs associated with diastolic heart failure are equivalent to those of systolic heart failure, although mortality is lower. Despite its prevalence, the physiology of diastolic failure is poorly understood, the optimal diagnostic strategy has yet to be defined, and no therapy has been shown to lower the mortality of the disease. In this research study hypertensive patients over age 65 years and age-matched controls will be studied using non- invasive measurements of arterial stiffness and myocardial relaxation. The impact of various vasodilators on these outcomes will be tested in order to determine whether disparate pharmacological effects on arterial stiffness lead to different effects on myocardial relaxation.