ACUPUNCTURE ANALGESIA, EXPECTANCY, AND PSYCHIATRIC COMORBIDITY IN PTS WIH LBP

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。镇痛作用是针灸和安慰剂研究最多的治疗效果之一。涉及针灸缓解疼痛的临床随机对照试验（RCT）往往报告矛盾或模棱两可的结果，这通常是由于“对照”组显示出与针灸治疗组相同数量级的有益治疗效果[1-4]。相比之下，基础科学研究调查针灸和安慰剂镇痛产生了明确的结果[5-8]，导致了具体的可验证的机制假说。本研究应用针灸镇痛的基础科学方法之前，管理的热疼痛的临床人群的腰痛患者，同时监测预期的缓解和控制精神并发症。这是阐明针灸成败机制的第一步。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Analgesia is one of the most studied therapeutic effects of both acupuncture and placebo. Clinical randomized controlled trials (RCTs) involving acupuncture for pain relief tend to report contradictory or equivocal outcomes often due to the fact that "control" groups exhibit beneficial treatment effects on the same order of magnitude as the acupuncture treatment groups [1-4]. In contrast, basic science research investigating both acupuncture and placebo analgesia has produced unequivocal results [5-8] that have led to specific testable mechanistic hypotheses. This study applies the basic science methodology of acupuncture analgesia prior to the administration of thermal pain to a clinical population of patients with low back pain, while monitoring expectations for relief and controlling for psychiatric comorbidity. This is a first step in elucidating mechanisms for success or failure of acupuncture.