TREATMENT FOR INFANTS AND CHILDREN WITH INTERMEDIATE-RISK NEUROBLASTOMA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究不再招募病人。(来自国家癌症研究所PDQ数据库的临床试验摘要)化疗中使用的药物使用不同的方法来阻止肿瘤细胞分裂，从而停止生长或死亡。联合使用多种药物可能会杀死更多的肿瘤细胞。联合化疗加手术可能是治疗神经母细胞瘤的有效方法。这项第三阶段试验正在研究联合化疗和手术治疗年轻神经母细胞瘤患者的效果。所有患者将在第1、3、6-7和9-10周接受1-3天的联合化疗。2个月以下的患者也将在完成化疗后24小时开始注射非格列西汀或沙格拉司汀，直到血细胞计数恢复正常。一些患者可能在12-13周、15周、18-19周和21周继续接受联合化疗。化疗完成后，患者将接受手术切除残留的肿瘤。然后，一些患者可能会接受放射治疗。患者将接受随访评估，每月一次，为期6个月，每2个月，为期6个月，每3个月，为期1年，每6个月，为期1年，此后每年1次

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is no longer recruiting patients. (Clinical trial summary from the National Cancer Institute's PDQ database) Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. Combination chemotherapy plus surgery may be an effective treatment for neuroblastoma. This Phase III trial is studying how well combination chemotherapy followed by surgery works in treating young patients with neuroblastoma. All patients will receive infusions of combination chemotherapy for 1-3 days during Weeks 1, 3, 6-7, and 9-10. Patients younger than 2 months old will also receive injections of filgrastim or sargramostim beginning 24 hours after completing chemotherapy and continuing until blood counts return to normal. Some patients may continue to receive combination chemotherapy in Weeks 12-13, 15, 18-19, and 21. Following completion of chemotherapy, patients will undergo surgery to remove residual tumor. Some patients may then receive radiation therapy. Patients will receive follow-up evaluations once a month for 6 months, every 2 months for 6 months, every 3 months for 1 year, every 6 months for 1 year, and once a year thereaf