EFFECT OF BARIATRIC SURGERY ON BONE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。肥胖是心血管疾病、糖尿病和癌症的危险因素。减肥已被证明可以提高胰岛素敏感性，减少心血管疾病的危险因素。Roux-en-Y胃旁路手术产生高达70%的多余体重的损失，并且该手术的长期体重减轻延长了10-14年。由于肥胖的医疗管理的有限成功，以及腹腔镜Roux-en-Y胃旁路术（LRGB）的并发症减少，更多的患者选择接受这种手术。最近的研究已经注意到，受试者在Roux-en-Y或可调节硅胶胃束带减肥后，骨吸收和骨丢失的标志物增加。这些研究表明，骨丢失发生在减肥手术后，尽管横截面设计和研究持续时间等限制限制了观察结果的有用性。在这项研究中，我们将测试的假设，骨丢失发生在减肥手术后，骨丢失的程度取决于性别，年龄和绝经时的手术。受试者将从卡梅尔圣文森特医院的大型减肥手术实践中招募。术后每3个月评价一次骨密度、血清和尿液骨代谢标志物，持续1年，然后在第二年每6个月评价一次。减肥手术后明显的骨质流失将最终导致干预措施，以预防这一人群的骨病。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity is a risk factor for the development of cardiovascular disease, diabetes, and cancer. Weight loss has been demonstrated to improve insulin sensitivity and reduce risk factors for cardiovascular disease. The Roux-en-Y gastric bypass procedure produces losses of up to 70% of excess body weight and long-term weight loss with this procedure extends out 10-14 yr. Because of the limited success of medical management of obesity, and reduced complications with laparoscopic Roux-en-Y gastric bypass (LRGB), more patients are opting to undergo this surgery. Recent studies have noted an increase in markers of bone resorption and bone loss in subjects following Roux-en-Y or adjustable silicone gastric banding for weight loss. These studies suggest that bone loss occurs following bariatric surgical procedures, although limitations such as cross sectional design and duration of study, restrict the usefulness of the observations. In this study we will test the hypothesis that bone loss occurs following bariatric surgery and that the extent of bone loss is dependent on gender, age and menopause at the time of surgery. Subjects will be recruited from a large bariatric surgical practice at St. Vincent's Hospital in Carmel. Bone density, serum and urine markers of bone metabolism will be evaluated every 3 months following surgery for 1 year, and then every 6 months in the second year. The demonstration of significant bone loss following bariatric surgery will ultimately lead to interventions to prevent bone disease in this population.