DISCOVERY AND ASSESSMENT OF GENETIC AND ENVIRONMENT

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。宿主遗传、获得性因素和环境影响影响许多慢性疾病的发生、严重程度、进展和结局，包括肝胆胰疾病。为了促进发现影响慢性疾病发生或进展的新遗传因素，我们需要建立组织和DNA库，并将多态性和突变分析结果（基因型）与患者和临床特征（表型）相关联。为了为这类研究提供必要的数据库，我们需要建立临床数据库、组织和DNA库。该项目旨在为在康涅狄格大学就诊的肝胆疾病患者实现这一目标，这些患者将因与本研究无关的原因接受肝脏活检。我们期望由此建立的数据库和标本储存库将使我们能够进行重要和信息丰富的新分析，并将成为未来新拨款和合同申请的基础。它将为其他疾病和失调的其他研究提供范例。这类研究的潜力很大。我们需要GCRC核心的支持，以使这些举措有一个成功的开端。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Host genetic, acquired factors and environmental influences affect the development, severity, progression, and outcome of many chronic diseases, including hepato-biliary-pancreatic diseases. To facilitate the discovery of new genetic factors that influence development or progression of chronic diseases, we need to develop tissue and DNA banks and correlate results of polymorphisms and mutational analyses (genotypes) with patient and clinical characteristics (phenotypes). To provide the necessary databases for such studies, we need to build-up clinical databases and tissue and DNA banks. This project is designed to accomplish this for patients with hepato-biliary diseases seen at UConn who will be undergoing liver biopsies for reasons unrelated to this study. We expect the database and specimen repository thus developed will allow us to perform important and informative new analyses, and will form the basis for new grant and contract applications in the future. It will serve as a paradigm for other studies in other diseases and disorders. The potential is great for studies of the kind. We need support from the GCRC cores in order to get these initiatives off to a successful start.