CLINICAL AND HORMONAL EFFECTS OF GHRP-2 IN ADULT PATIENTS WITH CYSTIC FIBROSIS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这是一项开放标签研究，将使用每例成年CF受试者作为其自身对照。目标如下：1）表征成年囊性纤维化患者响应于生长激素释放激素（GHRH）、低剂量GHRP-W + GHRH的组合以及低剂量GHRP-2和高剂量GHRP-2皮下的GH分泌生理学; 2）测定给予GHRP-2超过90天对IGF-1、GH、催乳素、瘦素、ANP和皮质醇以及对瘦体重、脂肪量的影响，和骨矿物质含量。还将评估肺功能的影响，通过最大吸气和呼气力、肺活量测定和运动耐量以及疾病特异性生活质量和呼吸困难指数进行测量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is an open-label study that will be performed with each adult CF subject acting as his/her own control. The objectives are as follows: 1) characterize the physiology of GH secretion in adult Cystic Fibrosis patients in response to growth hormone releasing hormone (GHRH), the combination of low dose GHRP-W + GHRH, and low dose GHRP-2 and high dose GHRP-2 subcutaneously; 2) Determine the effects of GHRP-2 given over 90 days on IGF-1, GH, prolacitn, leptin, ANP and cortisol and on lean body mass, fat mass, and bone mineral content. There will also be evaluations of the effects of pulmonary function as measured by the maximal inspiratory and expiratory forces, spirometry and exercise tolerance, as well as disease-specific quality of life and dyspnea indices.