EFFECTS OF TETRACYCLINES ON ACUTE PHASE PROTEINS IN SMOKERS W PERIODONTITIS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。在这个项目中，我们建议1)确认吸烟、牙周病和急性时相反应的生物标志物之间的联系，作为夸大全身炎症的指标，以及2)测试四环素对吸烟者和烟雾暴露动物模型循环炎症细胞功能、牙周病的生物标志物和全身炎症的急性期标志物的影响。我们的假设是，四环素类药物会降低全身炎症标志物的水平，因为它们可以减轻牙周炎的严重程度。由于CMT-3的第一阶段研究尚未完成，我们最初建议用亚抗菌剂量的多西环素(Periostat)治疗一组患有牙周病的人类吸烟者，作为目前推荐的常规牙周管理标准的补充，并通过一组可以进行最小侵入性的生物标志物分析来评估他们的反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this project, we propose to 1) confirm the link between smoking, periodontal disease and biomarkers of the acute phase response as indicators of exaggerated systemic inflammation, and 2) test the effects of tetracyclines on circulating inflammatory cell function, biomarkers of periodontal disease, and the acute phase markers of systemic inflammation in smokers as well as smoke-exposed animal models. Our hypothesis is that the tetracyclines will lower the levels of the markers of systemic inflammation as they reduce the severity of periodontitis. Because the Phase I studies on CMT-3 are not yet complete, we propose initially to treat a cohort of human smokers with periodontal disease with a subantimicrobial dose of doxycycline (Periostat¿), adjunctive to routine standard of periodontal management as currently recommended, and evaluate their response through a panel of biomarker assays which can be performed with minimal invasiveness.