GENETIC EPIDEMIOLOGY OF ENERGY METABOLISM

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。这项研究的目的是更好地了解基因如何影响12至16岁非洲裔美国女孩的静息能量消耗，这可能有助于青春期肥胖的发展。本研究分为两个部分。最初，我们将对1000名女孩进行口腔筛查以进行基因分型。那些与我们感兴趣的特定基因相匹配的人，将被要求在辛辛那提儿童医院医学中心的综合临床研究中心进行一次通宵访问。在过夜访视时，受试者将测量身体组成，如身高、体重和皮褶。受试者还将接受DXA扫描、抽血和静息能量测试。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to better understand how genes may influence resting energy expenditure in 12 ¿ 16 year old African American girls which may contribute to the development of obesity during adolescence. There are two parts to the study. Initially, we will buccal screen 1000 girls for genotyping. Those that are a match the specific genes we are interested in, will be asked to come for an overnight visit at Cincinnati Children's Hospital Medical Center's General Clinical Research Center. At the overnight visit, the subject will have measurements of body composition such as height, weight and skinfolds. The subject will also have a DXA scan, blood draw, and a Resting Energy test.