ADRENAL SUPPRESSION IN INFANTS WITH HEMANGIOMA

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这是一项前瞻性观察队列研究，旨在评估长期使用糖皮质激素和下丘脑-垂体-肾上腺轴治疗血管瘤婴儿的效果。值得关注的是，接受高剂量糖皮质激素治疗的婴儿可能出现肾上腺功能不全，无论是全身糖皮质激素还是局部给药糖皮质激素。每组12例患者将进行合成acth测试，并与12例对照组进行肾上腺功能不全的比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a prospective observational cohort study to evaluate the effects of long term treatment with glucocorticoids and the hypothalamic-pituitary-adrenal axis in infants with hemangioma. Concern is that infants treated with high-dose glucocorticoids may develop adrenal insufficiency, either with systemic glucocorticoids or topically administered glucocorticoids. Twelve patients of each group will be studied with synthetic ACTH-testing and compared for adrenal insufficiency with 12 controls.