HOST MODULATION/PERIODONTAL THERAPY EFFECTS ON DIABETES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究的目的是确定药物Periostat是否会减少I型糖尿病患者的牙周病。牙周病会导致牙龈发炎，并可能导致牙齿脱落。Periostat是一种已被食品和药物管理局批准用于治疗非糖尿病患者牙周病的药物。已经表明，当使用该药物时，沿着标准的牙齿和牙根清洁，非糖尿病患者的牙龈疾病比仅用牙齿和牙根清洁治疗的患者有更大的改善。一旦研究结束，我们应该知道药物Periostat是否对治疗I型糖尿病患者的牙周病和全身炎症有用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine if the drug Periostat will reduce periodontal disease in persons with Type I diabetes. Periodontal disease causes inflammation of the gums and can result in tooth loss. Periostat is a drug that has been approved by the Food and Drug Administration for the use in the treatment of periodontal disease in non-diabetic persons. It has been shown that when the drug is used, along with standard tooth and root cleaning, non-diabetic patients have greater improvement in their gum disease than patients treated only with tooth and root cleaning. Once the study is concluded we should know if the drug Periostat is useful for the treatment of periodontal disease and whole body inflammation in persons with Type I diabetes.