HEPATITIS C PREVALENCE IN PERINATALLY INFECTED HIV-INFECTED CHILDREN

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这是一项丙型肝炎病毒（HCV）感染的患病率研究。600例入组PACTG 219 C的年龄大于或等于1岁至小于21岁的围产期感染HIV的儿童将入组本子研究。单次抽血进行HCV抗体（酶免疫测定-EIA）检测和HCV RNA（聚合酶链反应-PCR）检测。HCV阴性受试者接受1次访视; HCV检测结果阳性受试者接受2次访视; HCV检测结果不一致受试者接受2次或3次访视。本研究的主要目的是确定随机选择的PACTG 219 C中围产期感染HIV阳性儿童的丙型肝炎患病率。其他目的是进行描述性分析的可能的辅助因素在围产期传播丙型肝炎病毒;进行描述性分析的临床症状和肝功能检查的受试者被发现是HCV感染;比较性能的HCV抗体检测（EIA）和HCV RNA PCR检测的儿童;并实现样本丙型肝炎病毒检测在未来的日期。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a prevalence study of Hepatitis C Virus (HCV) infection. 600 perinatally-infected HIV-infected children greater than or equal to one year to less than 21 years of age who are enrolled in PACTG 219C will be enrolled in this substudy. A single blood draw for HCV antibody (EnzymeImmunoassay-EIA) testing and HCV RNA (Polymerase Chain Reaction-PCR) testing. One visit for HCV negative subjects; two visits for subjects with positive HCV test results; two or three visits for subjects discordant HCV test results. The primary objective of this study is to determine the prevalence of Hepatitis C in a randomly selected subset of perinatally-infected HIV-positive children enrolled in PACTG 219C. Other objectives are to perform descriptive analyses of possible co-factors in the perinatal transmission of Hepatitis C virus; to perform descriptive analyses of clinical symptoms and liver function tests in subjects found to be HCV-infected; to compare the performance of HCV antibody testing (EIA) and HCV RNA PCR testing in children; and to achieve samples for Hepatitis C virus testing at a future date.