ASSOCIATION BETWEEN PERIODIC LIMB MOVEMENT DISORDERS AND FERRITIN LEVEL IN CHILD

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。周期性肢体运动障碍是指睡眠期间腿部和手臂反复运动的情况。随着年龄的增长，患病率有明显的上升趋势。这种疾病可能发生在幼儿身上。这种情况会扰乱睡眠，导致儿童无法入睡、白天过度嗜睡或多动。目前还没有FDA批准的治疗儿童PLMD的药物。目前，儿科睡眠专家常用并被美国睡眠医学会推荐用于治疗儿童PLMD的药物包括氯硝西潘、多巴胺受体激动剂和左旋多巴。本研究旨在探讨儿童PLMD与铁蛋白水平的关系。此外，铁蛋白水平低(&lt；50 ng/ml)的儿童将接受硫酸亚铁治疗。治疗的反应将通过症状和活动图的改善来监测。动作记录仪是一款儿童睡眠时戴在手腕上的小型手表，它记录了睡眠期间手臂运动的频率。我们的目标是寻找像铁这样的简单药物是否可以用来治疗患有周期性肢体运动障碍的儿童。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Periodic Limb Movement Disorder refers to the condition which repetitive movements of legs and arms occurs during sleep. There is a clear tendency for the prevalence to increase with age. This disorder can occur in young children. This condition disturbs sleep and leads to the inability to sleep, excessive daytime sleepiness or hyperactivity in children. There is no FDA approved medication for PLMD in children. The current medications that are commonly used by pediatric sleep specialists and are recommended by the American Academy of Sleep Medicine for treatment of PLMD in children include Clonazepam, Dopamine receptor agonists and Levadopa. This study is aimed to evaluate the relationship between PLMD and ferritin level in children. In addition, children who have low ferritin level (<50ng/ml) will receive treatment with ferrous sulfate. The response of treatment will be monitored by improvement in the symptoms and actigraphy. The actigraphy is a small watch that children wear on the wrist during sleep and it records the frequency of arm movements during sleep. Our aim is to find if simple medication like iron can be used to treat children with periodic limb movement disorder.