ALZHEIMER'S DISEASE NEUROIMAGING INITIATIVE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。目前，阿尔茨海默病（alzheimer 's disease， AD）的诊断和准确预测其发展是很困难的。这项多中心研究将着眼于脑成像和其他生物测试（生物标志物）在检测AD及其进展中的作用。参与者包括：1)早期AD， 2)正常记忆和思维，或3)轻度认知障碍（MCI）的老年人，MCI通常代表正常衰老和AD之间的过渡状态。受试者将接受约6个月的访谈和检查、认知测试和脑磁共振成像（MRI），为期2-3年。将采集血液和尿液样本。一部分受试者还将接受连续的正电子发射断层扫描（PET）脑成像。在研究期间，将从同意腰椎穿刺的受试者中收集两次脑脊液。从所有地点的参与者那里收集的信息和样本将集中存储，并可用于帮助研究人员设计未来的研究，以治疗或预防阿尔茨海默病。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Currently, it is difficult to diagnose Alzheime's disease (AD) and predict its progression with certainty. This multicenter study will look at the usefulness of brain imaging and other biological tests (biomarkers) in detecting AD and its progression. Participants will include older adults with either: 1) early AD, 2) normal memory and thinking, or 3) mild cognitive impairment (MCI), a condition that often represents a transitional state between normal aging and AD. Subjects will undergo interviews and examinations, cognitive testing, and brain magnetic resonance imaging (MRI) at approximately 6-month intervals for 2-3 years. Blood and urine samples will be collected. A subset of subjects will also undergo serial positron emission tomography (PET) brain imaging. Cerebrospinal fluid will be collected twice during the study from those subjects agreeing to have a lumbar puncture. Information and samples collected from participants at all sites will be stored centrally and made available to help researchers design future studies to treat or prevent Alzheimer's disease.