THE IRON ION-MYCOPHENOLATE MOFETIL CHELATION COMPLEX INTERACTION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究是为了评估两种药物之间的相互作用，铁和霉酚酸酯，这两种药物经常用于肾移植受者。很大一部分移植人群，特别是肾移植受者，经历了需要补充铁质的贫血。在最近对正常健康志愿者进行的一项研究中，观察到在补充铁的情况下服用霉酚酸(血液中霉酚酸酯药物的标志)水平显著降低。代表稳定的门诊肾移植人群的20名患者将被招募。这项研究旨在确定在以下几种情况下这种相互作用的程度和程度：1)当与霉酚酸酯同时服用铁时；2)当在霉酚酸酯服用2小时后服用铁时；3)本研究还将检查与速释和缓释铁产品的相互作用的影响。这项研究的结果可能会提供更好地指导这些药物在移植人群中的使用的信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is being performed to assess the interaction between two medications, iron and mycophenolate mofetil, which are frequently used in kidney transplant recipients. A large portion of the transplant population, particularly renal allograft recipients, experience anemia requiring iron supplementation. In a recent research study performed in normal healthy volunteers, it was observed that mycophenolic acid levels (the marker for the drug mycophenolate mofetil in the blood) were significantly lower when taken with an iron supplement. Twenty patients representative of the stable outpatient renal transplant population will be recruited. This study is designed to determine the extent and magnitude of this interaction under several conditions: 1) when iron is taken at the same time as mycophenolate mofetil; 2) when iron is taken two hours after mycophenolate mofetil; 3) this study will also examine the effects of interaction with immediate release and sustained release iron products. The results of this study may provide information that will better direct the use of these medications in the transplant population.