ECG-GATED 16-SLICE CTCA: COMPARISON WITH CATHETER CORONARY ANGIOGRAPHY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。冠状动脉疾病最终可能导致心脏病发作，它是美国的主要死亡原因，占2000年美国所有死亡人数的30%(NIH统计数据)。密歇根州的冠心病年龄调整死亡率在美国排名第四。导管冠状动脉造影术是目前可用于检测心脏主要血管血流问题的最佳诊断工具，但它是一种具有许多相关风险的侵入性操作。我们想确定使用较新的更快的层CT扫描仪(心脏和心脏主要动脉的CAT扫描)进行CT冠状动脉成像是否是诊断冠心病的准确成像方式。这项研究希望表明，通过使用新的CT扫描技术，我们将能够比心脏导管术更准确、更安全地诊断心脏疾病。18岁或以上的男性和女性可以参加这项研究，他们计划由医生进行心脏插管手术。我们将招募既有或从未接受过心脏介入治疗的受试者，如血管成形术、支架置入术或冠状动脉旁路手术。如果CT冠状动脉造影术被证明是一种强大的成像工具，它可能会对胸痛和不典型胸痛的患者都有用，因为很难确定胸痛是否源于心脏。CT的潜在优势包括与心导管检查相比辐射剂量更低，以及更多可能患有心脏病的人可能选择这种非侵入性测试。这项测试也可能被证明比心导管术更便宜。如果CT对冠状动脉疾病的诊断是准确的，就有可能使用CT来筛查具有冠状动脉疾病高危因素的无症状个体；长期目标是减少急性心脏事件和冠状动脉疾病的死亡。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Disease of the coronary arteries, which may ultimately lead to a heart attack, is the leading cause of death in the United States, accounting for 30% of all deaths in the United States in the year 2000 (NIH statistics). The state of Michigan has the 4th highest age-adjusted death rate for CAD in USA. Catheter coronary angiography is currently the best diagnostic tool available to detect blood flow problems in the major vessels of the heart, however, it is a invasive procedure with many associated risks. We would like to determine if CT Coronary Angiography using the newer faster 64-slice CT scanner (a CAT Scan of your heart and major arteries of the heart) is an accurate imaging modality for diagnosing coronary artery disease. This study hopes to show that by using new CT scanning techniques we will be able to diagnose heart conditions accurately, and more safely, than heart catheterization. Men and women 18 years of age or older who are scheduled to have a heart catheterization by their physician can participate in this study. We will enroll subjects both who have had or have not had a previous heart intervention such as angioplasty, stent placement or coronary artery bypass surgery. If CT coronary angiography proves to be a robust imaging tool, it may become useful both in patients with chest pain, and atypical chest pain, when it is difficult to know whether the pain in the chest is originating from the heart or not. Potential advantages of CT include decreased radiation dose vs cardiac catheterization and that a greater number of people with possible heart disease may opt for this non-invasive test. The test may also prove to be less expensive than cardiac catheterization. If CT is accurate for the diagnosis of coronary artery disease, it may be possible to use CT to screen asymptomatic individuals with a high risk factor profile for coronary artery disease; with the long term goal of reducing acute cardiac events and death from coronary artery disease.