PILOT COLLABORATIVE PET IMAGING TRIAL

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。额颞叶痴呆（FTD）是一种导致行为和思维进行性恶化的脑部疾病。目前，由于症状与阿尔茨海默病（AD）、抑郁症等其他疾病重叠，很难准确诊断。重要的是要能够区分这些情况，以便提供最适当的咨询和治疗。这项研究调查了一种被称为正电子发射断层扫描（PET）的脑部扫描是否能提高医生诊断FTD的能力。本研究将招募到密歇根大学认知障碍诊所就诊的伴有FTD症状的患者。每个病人将有一个研究伙伴。研究伙伴必须年满18岁，而患者则为40岁或以上的成年人。所有受试者可以是任何性别或种族。患者将进行4次门诊研究访问和PET扫描。这4次研究访问将在18个月内进行。在每次研究访问中，患者将完成思维和行为测试，并由研究医生进行检查。PET扫描包括插入静脉导管，接受小剂量的放射性药物，然后躺在PET扫描仪的桌子上30分钟。研究伙伴将完成2项调查，并陪同患者进行所有研究访问。此外，来自其他评估的医疗记录将成为研究记录的一部分。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Frontotemporal dementia (FTD) is a brain disease that causes progressive worsening of behavior and thinking. Currently it is difficult to diagnose FTD accurately because symptoms overlap with other illnesses such as Alzheimer s disease (AD) and depression. It is important to be able to distinguish these conditions in order to provide the most appropriate counseling and treatment. This study investigates whether a type of brain scan called positron emission tomography (PET) can improve a physician s ability to diagnose FTD. This study will recruit patients who come to the University of Michigan Cognitive Disorders Clinic with symptoms of FTD. Each patient will have a study partner. Study partners must be 18 years or older, while patients will be adults 40 years or older. All subjects may be of any gender or race. Patients will have 4 outpatient study visits and a PET scan. The 4 study visits will occur over 18 months. At each research visit, patients will complete tests of thinking and behavior and be examined by a study physician. The PET scan involves inserting an intravenous catheter, receiving a small dose of a radiopharmaceutical, and lying on a table in the PET scanner for 30 minutes. Study partners will complete 2 surveys and accompany patients to all study visits. In addition, medical records from other evaluations will become part of study records.