THE ATHEROSCLEROSIS PREVENTION IN PEDIATRIC LUPUS ERYTHEMATISIS (APPLE) STUDY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。系统性红斑狼疮（SLE）是一种罕见的、可能危及生命的全身血管炎症的自身免疫性疾病。SLE的病因尚不清楚。这种疾病可以影响几个或多个器官系统。在儿童中，最常见的器官是皮肤、关节、肾脏、心脏和大脑。一般来说，儿童SLE比成人更严重，因为受影响的器官更多，受影响也更严重。儿童SLE通常需要积极和长期的类固醇和化疗治疗。动脉粥样硬化是一种常见于老年人的疾病，是由血管内壁的脂肪沉积引起的血管狭窄引起的。动脉粥样硬化会增加心肌梗死和中风的风险。降脂药物已被开发出来，以降低血液中的脂肪含量，防止脂肪进一步粘附在血管内壁上，并溶解血管上的脂肪沉积。这些药物已被证明可以降低心脏病发作和中风的风险。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Systemic Lupus Erythematosus (SLE) is an uncommon, potentially life-threatening, autoimmune disease of inflammation of the blood vessels all over the body. The cause of SLE is unknown. The disease can affect a few organ systems or many. In children, the most common organs affected are the skin, the joints, the kidney, the heart and the brain. In general, childhood SLE is more severe than it is in adults because more organs are affected and affected more severely. Childhood SLE often requires aggressive and long-term treatment with steroids and chemotherapy. Atherosclerosis is a disease common in older adults and is caused by a narrowing of the blood vessels caused by fatty deposits to the lining of the vessels. Atherosclerosis increases the risk of cardiac infarction and stroke. Lipid-lowering drugs have been developed to lower the fat content in blood, prevent further fat from sticking to the lining of blood vessels and also to dissolve fatty deposit on blood vessels. These drugs have been shown to reduce the risk of heart attack and stroke.