兄弟姐妹评估在预防西班牙裔儿童儿科 NAFLD 中的作用-猫眼课题宝

兄弟姐妹评估在预防西班牙裔儿童儿科 NAFLD 中的作用

批准号：

10675355

负责人：

MIRIAM B. VOS

金额：

$37.01万

依托单位：

EMORY UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2022

资助国家：

美国

项目状态：

未结题

起止时间：

2022-09-12 至 2026-01-31

来源：

https://reporter.nih.gov/project-details/10675355

关键词：

9 year old Administrative Supplement Adolescent Adult Affect Age Birth Order Black Populations Cardiovascular Diseases Cause of Death Characteristics Child Childhood diabetes Collaborations Communities Diabetes Mellitus Diabetes prevention Diet Dietary Intervention Disease Education Ethnic Origin Exposure to Family Family history of Family member Fatty Liver Food Funding Future Genetic Glucose Health Promotion Hispanic Hispanic Populations Household Image Insulin Resistance Intervention Intervention Studies Juice Liver diseases Magnetic Resonance Methods Mexican Americans Names Non-Insulin-Dependent Diabetes Mellitus Not Hispanic or Latino Nutritionist Obesity Obesity associated liver disease Overweight Parents Participant Population Prevalence Prevention Prevention Research Randomized Randomized Clinical Trials Reduce health disparities Relative Risks Research Research Support Risk Risk Factors Sampling Studies Siblings Testing United States United States National Institutes of Health Youth age group design diabetes risk disorder prevention disorder risk experience gender difference health disparity high risk improved interest intervention effect knowledge base liver transplantation metabolic phenotype non-alcoholic fatty liver disease pediatric non-alcoholic fatty liver disease prepuberty prevent preventive intervention prospective test recruit response sugar treatment as usual trial comparing

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Abstract Nonalcoholic fatty liver disease (NAFLD) is an obesity-associated liver disease that affects an estimated 7 million children in the United States. It is the most common reason for liver transplantation in adults and increases long term risk of diabetes and cardiovascular disease. NAFLD disproportionately affects Hispanic children and is an exceptionally important health disparity. The original R01 study focuses on use of a low sugar diet intervention for prevention of NAFLD in pre-pubertal children. The proposed administrative supplement studies are designed to expand the project to siblings of the primary participant and to add assessment of response of diabetes risk factors to the intervention. The findings will have sustained and significant implications for health promotion in Hispanic children, reduce health disparities, and inform future prevention efforts for children at increased risk of NAFLD and diabetes.

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