Sibling Assessment in Prevention of Pediatric NAFLD in Hispanic Children

兄弟姐妹评估在预防西班牙裔儿童儿科 NAFLD 中的作用

• 批准号: 10675355
• 负责人: MIRIAM B. VOS
• 金额: $ 37.01万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-12 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10675355
• 关键词: 9 year old; Administrative Supplement; Adolescent; Adult; Affect; Age; Birth Order; Black Populations; Cardiovascular Diseases; Cause of Death; Characteristics; Child; Childhood diabetes; Collaborations; Communities; Diabetes Mellitus; Diabetes prevention; Diet; Dietary Intervention; Disease; Education; Ethnic Origin; Exposure to; Family; Family history of; Family member; Fatty Liver; Food; Funding; Future; Genetic; Glucose; Health Promotion; Hispanic; Hispanic Populations; Household; Image; Insulin Resistance; Intervention; Intervention Studies; Juice; Liver diseases; Magnetic Resonance; Methods; Mexican Americans; Names; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Nutritionist; Obesity; Obesity associated liver disease; Overweight; Parents; Participant; Population; Prevalence; Prevention; Prevention Research; Randomized; Randomized Clinical Trials; Reduce health disparities; Relative Risks; Research; Research Support; Risk; Risk Factors; Sampling Studies; Siblings; Testing; United States; United States National Institutes of Health; Youth; age group; design; diabetes risk; disorder prevention; disorder risk; experience; gender difference; health disparity; high risk; improved; interest; intervention effect; knowledge base; liver transplantation; metabolic phenotype; non-alcoholic fatty liver disease; pediatric non-alcoholic fatty liver disease; prepuberty; prevent; preventive intervention; prospective test; recruit; response; sugar; treatment as usual; trial comparing

Abstract Nonalcoholic fatty liver disease (NAFLD) is an obesity-associated liver disease that affects an estimated 7 million children in the United States. It is the most common reason for liver transplantation in adults and increases long term risk of diabetes and cardiovascular disease. NAFLD disproportionately affects Hispanic children and is an exceptionally important health disparity. The original R01 study focuses on use of a low sugar diet intervention for prevention of NAFLD in pre-pubertal children. The proposed administrative supplement studies are designed to expand the project to siblings of the primary participant and to add assessment of response of diabetes risk factors to the intervention. The findings will have sustained and significant implications for health promotion in Hispanic children, reduce health disparities, and inform future prevention efforts for children at increased risk of NAFLD and diabetes.

摘要 非酒精性脂肪性肝病（NAFLD）是一种肥胖相关的肝病， 据估计，美国有700万儿童。这是肝脏最常见的原因 在成年人中移植，并增加糖尿病和心血管疾病的长期风险。 NAFLD不成比例地影响西班牙裔儿童，是一个非常重要的健康问题。 差距最初的R01研究重点是使用低糖饮食干预预防 青春期前儿童的NAFLD。拟议的行政补充研究旨在 将项目扩大到主要参与者的兄弟姐妹，并增加对 糖尿病的危险因素进行干预。研究结果将持续并具有重要意义 对西班牙裔儿童健康促进的影响，减少健康差距， 未来的预防工作，为儿童在非酒精性脂肪肝和糖尿病的风险增加。