BONE MARROW SAMPLING FROM NORMAL SUBJECTS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究的目的是通过评估感染、炎症和副作用的发生来评估重组人粒细胞集落刺激因子在先天性中性粒细胞减少症、慢性特发性中性粒细胞减少症和周期性中性粒细胞减少症患者中的作用。根据该方案，SCN的分子和细胞基础的研究继续进行，并继续对接受G-CSF和其他疗法长期治疗的患者进行临床观察。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to assess the effects of recombinant human granulocyte colony stimulating factor in patients with congenital neutropenia, chronic idiopathic neutropenia, and cyclic neutropenia by assessment of occurrence of infections, inflammation and side effects. Under this protocol, investigations of the molecular and cellular basis for SCN continue as well as continued clinical observations of patients on long-term treatment with G-CSF and other therapies.