EPIDEMIOLOGY OF DIABETES INTERVENTIONS AND COMPLICATIONS (EDIC)

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这项长期观察性研究继续研究1型糖尿病的并发症。它检查与糖尿病的肾脏、大血管、眼睛和神经并发症的发展相关的因素。研究志愿者在1984年至1993年期间首次参加了糖尿病控制和并发症试验（DCCT）。每年进行一次访问，进行实验室和身体评估。眼科检查，心脏和循环状态扫描，以及认知技能评估都是间歇性的。在接下来的两年里，将完成对神经功能的更详细评估。到目前为止，已经发表了许多文章。值得注意的是，这项研究引入了一个名为“代谢记忆”的概念，作为糖尿病并发症的外观和进展差异的可能解释，尽管自DCCT完成以来多年来血糖控制几乎相等，但原始常规和强化治疗组之间仍然明显。在一项相关研究中，我们从华盛顿大学DCCT/EDIC受试者的139名一级亲属中获得了DNA、血液和尿液化学、血压和体型数据。这正在与从其他EDIC诊所的亲属那里收集的样本一起进行沿着分析。大多数亲属都出现在GCRC上，但其他人则通过电话采访和在当地医生办公室进行的“远程”实验室测试参与。正在研究数据，以了解DCCT/EDIC受试者有或没有糖尿病严重并发症的家庭群体中出现的DNA共性（如果有的话）。2002年9月至2004年8月期间，

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This long-term observational study continues to examine complications of type 1 diabetes. It examines factors associated with development of kidney, macrovascular, eye and nerve complications of diabetes. Study volunteers first participated in the Diabetes Control and Complications Trial (DCCT), between 1984 and 1993. Visits occur annually, for laboratory and physical assessment. Eye exams, scans for cardiac and circulatory status, and evaluations of cognitive skills are included on an intermittent basis. Over the next two years, more detailed assessments of neurological function will be completed. Numerous articles have been published so far. Notably, this study has introduced a concept called "metabolic memory" as a possible explanation for differences in the appearance and progression of diabetes complications that are still evident between the original conventional and intensive treatment groups, despite years of nearly equal glucose control since DCCT completion. In an allied study, we obtained DNA, blood and urine chemistry, blood pressure, and body size data from 139 first-degree relatives of the University of Washington DCCT/EDIC subjects. This is being analyzed along with samples collected from relatives at other EDIC clinics. Most of the relatives were seen on the GCRC, but others participated through phone interview and "remote" lab tests at their local physicians' offices. Data is being studied to see what DNA commonalities, if any, appear among family groups where the DCCT/EDIC subject does or does not have significant complications of diabetes. The relatives were seen on the GCRC between September 2002 and August of 2004