INNER CITY ASTHMA CONSORTIUM: URBAN ENVIRONMENT AND CHILDHOOD ASTHMA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究将前瞻性地评估环境因素在市中心儿童免疫反应和哮喘表型发展中的重要性。这种环境有几个独特的特点，可能会通过影响母亲和宫内环境，以及通过对婴儿时期免疫发育的持续影响来改变免疫发育。URECA研究将是一项为期三年的纵向前瞻性评估，从出生开始。要评估的主要结果是在生命的头三年中细胞因子失调的发展与三岁时反复喘息之间的关系。次要目标是评估环境因素在细胞因子失调、喘息和哮喘发生中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will prospectively assess the importance of environmental factors in relations to the development of immune responses and asthma phenotype in children in the inner city. This environment has several unique features that are likely to alter immune development by affecting the mother and the intrauterine environment, and also through continued effects on immune development during infancy. The URECA study will be a longitudinal prospective evaluation over a three year period, beginning at birth. The primary outcome to be evaluated is the relationship between the development of cytokine dysregulation in the first three years of life, to the acquisition of recurrent wheezing at the age of three years. Secondary objectives are to evaluate the effects of environmental factors on the development of cytokine dysregulaton, wheezing and asthma.