Atopy, Leptin and Potential Biomarkers of Comorbid Obesity and Asthma in Inner-City Schoolchildren

内城学童中特应性、瘦素以及共病肥胖和哮喘的潜在生物标志物

• 批准号: 9900741
• 负责人: PERDITA PERMAUL
• 金额: $ 19.7万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9900741
• 关键词: Accounting; Age; Allergens; Allergic; Allergic inflammation; Area; Asthma; Award; Basophils; Biological Markers; Biology; Biometry; Body mass index; Center for Translational Science Activities; Child; Childhood Asthma; Chronic Disease; Clinical; Clinical Research; Clinical Sciences; Cohort Studies; Collection; Consent; Data; Dust; Educational Activities; Enrollment; Environment; Environmental Epidemiology; Environmental Exposure; Extrinsic asthma; Five-Year Plans; Frequencies; Funding; Goals; Home environment; Human; Infrastructure; Institution; Intervention; Intervention Studies; Knowledge; Laboratories; Learning; Leptin; Link; Literature; Measures; Mediating; Mediator of activation protein; Mentors; Mentorship; Minority; Morbidity - disease rate; National Health and Nutrition Examination Survey; National Institute of Allergy and Infectious Disease; Obesity; Outcome; Overweight; Pediatric cohort; Phenotype; Physicians; Play; Population; Positioning Attribute; Prevalence; Public Health; Public Health Schools; Research; Research Personnel; Research Project Grants; Research Project Summaries; Research Training; Resources; Risk; Role; School-Age Population; Schools; Scientist; Serum; Students; Surface; Symptoms; Techniques; Time; Training; Translational Research; United States; United States National Institutes of Health; Universities; Work; aged; air sampling; airway inflammation; atopy; base; career; career development; clinical phenotype; cohort; comorbidity; effective therapy; elementary school; environmental allergen; epidemiology study; inner city; innovation; insight; leptin receptor; low socioeconomic status; mortality; multidisciplinary; novel; novel marker; obesity in children; patient oriented research; phenotypic data; potential biomarker; programs; receptor expression; recruit; skills; symposium; urban children

PROJECT SUMMARY Research: There is a growing body of literature showing an association between childhood obesity and asthma morbidity. For reasons not fully understood, overweight/obese children with asthma are at an increased risk for worse asthma, particularly those with lower socioeconomic status and living in inner-city areas. This proposal details a five-year plan to provide the candidate, Perdita Permaul, MD, with the training and expertise to evaluate the role body mass index plays in the relationship between allergic inflammation and asthma morbidity in an established cohort of inner-city children with asthma enrolled in the School Inner-City Asthma Study (PI: Phipatanakul). This important and unique study involves the collection of extensive allergic phenotypic and outcomes data and potential biomarkers linking these two chronic diseases. Moreover, she has included an innovative and novel translational piece to examine leptin receptor expression on human basophils across BMI percentiles and the role that leptin plays in basophil activation, uniting basophil biology with phenotypic and functional data. Candidate: Dr. Permaul's long-term goal is to become an independent clinical/translational NIH funded investigator focused on patient-oriented research in pediatric asthma, and more specifically, in studying the association between childhood obesity and asthma morbidity. In order to achieve this goal, her short-term career objectives are to obtain further didactic training in environmental epidemiology, clinical and translational research, advanced biostatistics, as well as practical skills in cohort building, exposure assessment, laboratory techniques and biomarker analysis. This will be accomplished with formal classes, fieldwork and collaborative work to learn how to recruit, consent, and maintain a cohort, benchwork, attendance at institutional/national conferences, and guidance from established mentors and a multidisciplinary advisory board with the relevant expertise. This will result in a unique combination of practical skills and scientific knowledge that will successfully position her for her first R01 application and an independent career as a physician-scientist. Environment: Dr. Permaul will perform her research training and career development activities at world- renowned major academic institutions. She will work under the mentorship of Dr. Phipatanakul, an expert in environmental epidemiology and asthma, in addition to an extraordinary team of researchers, including Drs. Wayne Shreffler, Carlos Camargo, and Brent Coull, who have committed their time, resources, and expertise to facilitate Dr. Permaul's career development and the successful completion of the proposed project. During this award period, Dr. Permaul will complete the Program in Clinical and Translational Science through the Harvard Clinical and Translational Science Center and formal coursework at the Harvard School of Public Health. The academic environment created by the mentor, the institution, Harvard University and its affiliates provides a fertile ground for learning and collaborating specific to her research.

项目总结 研究：越来越多的文献表明儿童肥胖与 哮喘发病率。由于不完全了解的原因，患有哮喘的超重/肥胖儿童处于 增加哮喘恶化的风险，特别是那些社会经济地位较低和居住在市中心的人 区域。这项提案详细说明了为候选人，医学博士Perdita Permaul提供培训的五年计划 以及评估体重指数在过敏性炎症和 在内城学校注册的内城儿童中哮喘发病率的确定队列 哮喘研究(PI：Phipatanakul)。这项重要而独特的研究涉及收集广泛的过敏反应 表型和结果数据以及连接这两种慢性病的潜在生物标记物。此外，她还拥有 包括一篇研究人类嗜碱性粒细胞上瘦素受体表达的创新和新颖的翻译文章 通过BMI百分位数和瘦素在嗜碱性细胞激活中所起的作用，将嗜碱性细胞生物学和 表型和功能数据。 候选人：Permaul博士的长期目标是成为一家由NIH资助的独立临床/翻译机构 研究人员专注于儿童哮喘的以病人为中心的研究，更具体地说，在研究 儿童肥胖与哮喘发病率之间的关系。为了实现这一目标，她的短期 职业目标是获得环境流行病学、临床和翻译方面的进一步教学培训 研究、高级生物统计学以及在队列建设、暴露评估、实验室方面的实用技能 技术和生物标志物分析。这将通过正式课程、实地考察和协作来完成 努力学习如何招募、同意和维持一批人、基准工作、机构/国家机构的出勤率 会议，以及来自现有导师和多学科咨询委员会的指导， 专业知识。这将导致实践技能和科学知识的独特结合，这将 成功地为她的第一次R01申请和作为一名内科科学家的独立职业生涯奠定了基础。 环境：Permaul博士将在World-World进行她的研究、培训和职业发展活动 著名的主要学术机构。她将在菲帕塔纳库尔博士的指导下工作，菲帕塔纳库尔博士是一位 环境流行病学和哮喘，此外还有一支非凡的研究团队，包括Dr。 Wayne Shreffler、Carlos Camargo和Brent Coull，他们投入了时间、资源和专业知识 为Permaul博士的职业发展和拟议项目的圆满完成提供便利。在.期间 在此授奖期间，Permaul博士将通过以下方式完成临床和翻译科学计划 哈佛临床与转化科学中心和哈佛公共学院的正式课程 健康。导师、机构、哈佛大学及其附属机构创造的学术环境 为她的研究提供了学习和合作的肥沃土壤。