Atopy, Leptin and Potential Biomarkers of Comorbid Obesity and Asthma in Inner-City Schoolchildren

项目摘要 研究：越来越多的文献表明儿童肥胖与肥胖之间存在联系， 哮喘发病率由于尚不完全清楚的原因，超重/肥胖的哮喘儿童处于一个危险的水平。 哮喘恶化的风险增加，特别是那些社会经济地位较低和生活在市中心的人 地区该提案详细说明了为候选人Perdita Permaul，MD提供培训的五年计划 和专业知识来评估身体质量指数在过敏性炎症和 在一个已建立的市中心哮喘儿童队列中， 哮喘研究（PI：Phipatanakul）。这项重要而独特的研究涉及收集广泛的过敏性 表型和结果数据以及将这两种慢性疾病联系起来的潜在生物标志物。此外，她 包括一个创新的和新的翻译片段，检查瘦素受体表达的人嗜碱性粒细胞 以及瘦素在嗜碱性粒细胞活化中的作用，将嗜碱性粒细胞生物学与 表型和功能数据。 候选人：Permaul博士的长期目标是成为一个独立的临床/翻译NIH资助 研究人员专注于儿童哮喘患者导向的研究，更具体地说， 儿童肥胖与哮喘发病率之间的关系。为了实现这一目标，她的短期 职业目标是获得进一步的教学培训，在环境流行病学，临床和翻译 研究、先进的生物统计学以及队列建设、暴露评估、实验室方面的实用技能 技术和生物标志物分析。这将通过正式课程，实地考察和协作来完成 努力学习如何招募，同意和维持队列，钳工，参加机构/国家 会议，并从既定的导师和多学科咨询委员会的指导与有关的 专业知识这将导致实践技能和科学知识的独特结合， 成功地定位她为她的第一个R 01应用程序和一个独立的职业生涯作为一个物理学家，科学家。 环境：Permaul博士将在世界各地开展她的研究培训和职业发展活动- 著名的主要学术机构。她将在Phipatanakul博士的指导下工作， 环境流行病学和哮喘，除了一个非凡的研究团队，包括博士。 韦恩什里夫勒、卡洛斯卡马戈和布伦特库尔，他们投入了时间、资源和专业知识 促进Permaul博士的职业发展和成功完成拟议项目。期间 在此期间，Permaul博士将完成临床和转化科学计划，通过 哈佛临床和转化科学中心和哈佛公共管理学院的正式课程 健康由导师、机构、哈佛大学及其附属机构创造的学术环境 为她的研究提供了一个学习和合作的沃土。

PROJECT SUMMARY Research: There is a growing body of literature showing an association between childhood obesity and asthma morbidity. For reasons not fully understood, overweight/obese children with asthma are at an increased risk for worse asthma, particularly those with lower socioeconomic status and living in inner-city areas. This proposal details a five-year plan to provide the candidate, Perdita Permaul, MD, with the training and expertise to evaluate the role body mass index plays in the relationship between allergic inflammation and asthma morbidity in an established cohort of inner-city children with asthma enrolled in the School Inner-City Asthma Study (PI: Phipatanakul). This important and unique study involves the collection of extensive allergic phenotypic and outcomes data and potential biomarkers linking these two chronic diseases. Moreover, she has included an innovative and novel translational piece to examine leptin receptor expression on human basophils across BMI percentiles and the role that leptin plays in basophil activation, uniting basophil biology with phenotypic and functional data. Candidate: Dr. Permaul's long-term goal is to become an independent clinical/translational NIH funded investigator focused on patient-oriented research in pediatric asthma, and more specifically, in studying the association between childhood obesity and asthma morbidity. In order to achieve this goal, her short-term career objectives are to obtain further didactic training in environmental epidemiology, clinical and translational research, advanced biostatistics, as well as practical skills in cohort building, exposure assessment, laboratory techniques and biomarker analysis. This will be accomplished with formal classes, fieldwork and collaborative work to learn how to recruit, consent, and maintain a cohort, benchwork, attendance at institutional/national conferences, and guidance from established mentors and a multidisciplinary advisory board with the relevant expertise. This will result in a unique combination of practical skills and scientific knowledge that will successfully position her for her first R01 application and an independent career as a physician-scientist. Environment: Dr. Permaul will perform her research training and career development activities at world- renowned major academic institutions. She will work under the mentorship of Dr. Phipatanakul, an expert in environmental epidemiology and asthma, in addition to an extraordinary team of researchers, including Drs. Wayne Shreffler, Carlos Camargo, and Brent Coull, who have committed their time, resources, and expertise to facilitate Dr. Permaul's career development and the successful completion of the proposed project. During this award period, Dr. Permaul will complete the Program in Clinical and Translational Science through the Harvard Clinical and Translational Science Center and formal coursework at the Harvard School of Public Health. The academic environment created by the mentor, the institution, Harvard University and its affiliates provides a fertile ground for learning and collaborating specific to her research.