PHENOTYPING IMMUNE-BASED DEPRESSION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究将探讨IFN-a治疗丙型肝炎感染引起的抑郁的生理学。一般的假设是，与两个对照组相比，接受IFN-a治疗的未发生抑郁症的丙型肝炎患者和未开始使用IFN-a治疗的未发生抑郁症的丙型肝炎患者，在接受IFN-a治疗时发生抑郁症的患者会表现出夜间核心体温、基础代谢率、睡眠模式和细胞因子水平（IL-6、IL-1a/b和TNFa）的变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will investigate the physiology of depression induced by administration of IFN-a for the treatment of hepatitis C infection. The general hypothesis is that patients who develop depression while receiving IFN-a will demonstrate changes in nighttime core body temperature, basal metabolic rate, sleep patterns, and cytokine levels (IL-6, IL-1a/b, and TNFa), when compared with two control groups: IFN-a treated hepatitis C patients who do not develop depression and hepatitis C patients who are without depression and have not been started on IFN-a.