DEPRESSION DIABETES MECHANISMS: URBAN AFRICAN AMERICANS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这项研究将确定抑郁症的患病率和暴露于创伤的患者最初提出的格雷迪糖尿病诊所，并在GCRC，定义通过抑郁症导致代谢失衡的生物途径。这项研究还将确定通过随机、安慰剂对照、双盲试验治疗抑郁症是否会影响代谢平衡，改善总体血糖控制和患者对计划复诊和药物使用的依从性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will determine the prevalence of depression and exposure to trauma in patients initially presenting to the Grady Diabetes Clinic and, in the GCRC, define the biologic pathways through which depression contributes to metabolism imbalance. This study will also ascertain whether treatment of depression via a randomized, placebo-controlled, double-blind trial affects metabolic balance and improves overall glycemic control and patient adherence to scheduled return appointments and use of medication.