ANTIDEPRESSANT EFFECTS ON EARLY LIFE STRESS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这项研究旨在确定情感治疗对患有严重抑郁症的人的影响，这些人没有或有童年时期身体或性虐待的历史。将检查三个主要领域以确定以下内容：1)哪种抗抑郁药在减少抑郁、担忧、愤怒或控制行为方面最有效；2)哪种抗抑郁药对身体功能的正常化更有效；3)上述身体机能的改变是否与情绪状态的改善同时发生。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study seeks to determine the effects of emotional treatment of people with major depression without and with a history of childhood physical or sexual abuse. Three major areas will be examined to determine the following: 1)which antidepressant is most effective in reducing feelings of depression, worry, anger or controlling behavior; 2) which antidepressant is more effective in normalizing aspects of physical function; and 3) whether changes in physical function mentioned above occur at the same time as improvement in emotional state.